Title: Hybrid Drug Nanoforms with Metal Nanoparticles in the Controlled Antibiotic Drug Delivery

Abstract

Cryochemical modification is a powerful method of reducing the size of drug substances particles, changing their form and crystal structure in order to improve their pharmaceutical properties. A possible application of this method allowed us to obtain antibiotics nanocrystals and hybrid nanoforms of metal particles and drug substances. The use of antibiotics and other antimicrobial agents in medicine has led to the emergence of many resistant strains of microorganisms. This problem is solved by the synthesis of new antibiotic substances and simultaneous use of hybrid nanoforms of antibiotics and metals nanoparticles. Antibacterial compositions were produced by low temperature freeze drying technique of water solution containing metal nanoparticles and antibacterial components. The thorough investigations TEM, electron microdiffraction, Fourier transformation infrared spectroscopy (FTIR), UV absorption spectroscopy, X-ray diffraction, differential thermal analysis (DTA) were made, It was shown that the hybrid compositions were including Ag,Cuand Fe/or metal oxide nanoparticles of 5-70 nm in diameter and nanoparticles of antibiotics of 50-350 nm in diameter. Drug cryoforms possessed modified crystal structures and lower melting temperatures, New cryoformed hybrid compositions of nanosized metal and antibiotic particles demonstrates higher antibacterial activity against E. coli 52, S.aureus 144, M. cyaneum 98, B. cereus 9 compared to the original drug substance and individual metal nanoparticles. Cryomodified forms of dioxidine and hentamicine, as also hybrid nanoforms of these antibacterial substances with metal nanoparticles have been included in polymer filmsofpolyvinyl alhogol (PVA), polyvinylpyrrolidone (PPV) and gelatine. It was shown the possibility of directed delivery and controlled release of antimicrobial components, as also higher biomedical activity of hybrid nanoforms against E. coli 52, S.cureus 144 compared to the individual components.

Biography

Tatyana I. Shabatina wasgraduated with honor in 1978 from Department of Chemistry, Moscow State University, in 1984 received Ph.D. in Physical Chemistry, Department of Chemistry, Moscow State University, title of work: Dimerization of nitrosocompounds and photoinduced nitroxide radicals formation in nematic liquid crystals, under supervision of Prof. Gleb B. Sergeev, in 2013 became Doctor of Chemical Sciences, specialization in Physical Chemistry, Department of Chemistry, Moscow State University, title of work “Molecular association and cryoformation of hybrid metal-mesogenic nanosystems with controlled morphology and structure”. From 2014 till now – Head of the Laboratory on Low Temperature Chemistry at Department of Chemistry M.V. Lomonosov Moscow State University. 1994 - research training at Max-Plank Institute, Muelheim (Germany), 1996 –research training in the University of Amsterdam (Nederland), 2000 – research visit in the Kansas State University (USA), 2009 – Visiting Professor, exchange visit in the University of York (UK).Research interests: NanoChemistry, Cryochemistry, Hybrid Metal Mesogenic Nanosystems, Nanostructured Films, Nanoforms of Drugs, Nanosized Metals, Spectroscopy at Low Temperatures.