Title: Evaluation of the effects of nanoparticles on the therapeutic function of platelet: A review

Abstract

Objectives: Nanotechnology and nanoparticles can be used in the blood disease monitoring and therapy. Nanoparticles have various effects on blood components and can reduce or improve the function of therapeutic platelet during the storage time. This review study was performed to evaluate the impacts of nanoparticles with various sizes and charges on platelet function and storage time. The present review contains the literature reported between 2010 and 2020. The data have been used from different sites such as PubMed, Wiley, Science Direct and on-line electronic journals. Results and discussion: The literature survey demonstrated that among various properties, size and charge of nanoparticles were critical on the function of therapeutic platelet during the storage and inhibition of their aggregation. Overall, this study described that nanoparticles with smaller size and negative charge were more effective in increasing the survival time, inhibition of aggregation and improving the function of the therapeutic platelet. Summary Based on the current review, it confirmed that nanoparticles such as dendrimer, Au, Ag and iron oxide nanoparticles with smaller size and negative charge have significant advantages for improving the efficacy of platelets during the storage chain and inhibition of their aggregation.